THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
Open Access
- 1 June 1971
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 49 (3) , 692-701
- https://doi.org/10.1083/jcb.49.3.692
Abstract
Emetine is a potent inhibitor of protein synthesis in sea urchin embryos. At a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95%, uridine incorporation into RNA continues for more than 1 hr and presumptive histone messenger RNA is synthesized and transported into the cytoplasm where it is apparently associated with polyribosomes. Possible explanations of this result and its implications for the "informasome" theory of messenger transport in embryonic cells are discussed.Keywords
This publication has 23 references indexed in Scilit:
- Synthesis of protein for DNA replication and cleavage events in the sand dollar embryoExperimental Cell Research, 1969
- Identification in Cleaving Embryos of Three RNA Species serving as Templates for the Synthesis of Nuclear ProteinsNature, 1969
- Control of haemoglobin synthesis: Rate of translation of the messenger RNA for the α and β chainsJournal of Molecular Biology, 1969
- THE REGULATION OF RNA SYNTHESIS AND PROCESSING IN THE NUCLEOLUS DURING INHIBITION OF PROTEIN SYNTHESISThe Journal of cell biology, 1969
- Synthesis of ribosomal RNA during sea urchin developmentBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
- Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells.1968
- STRUCTURAL BASIS FOR INHIBITION OF PROTEIN SYNTHESIS BY EMETINE AND CYCLOHEXIMIDE BASED ON AN ANALOGY BETWEEN IPECAC ALKALOIDS AND GLUTARIMIDE ANTIBIOTICSProceedings of the National Academy of Sciences, 1966
- The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte systemJournal of Molecular Biology, 1966
- The effect of HeLa cell cytoplasm on the rate of sedimentation of RNA.Proceedings of the National Academy of Sciences, 1966
- Messenger RNA decay and protectionJournal of Molecular Biology, 1964