IODINE-131-LABELED DIPHOSPHONATES FOR PALLIATIVE TREATMENT OF BONE METASTASES .2. PRELIMINARY CLINICAL-RESULTS WITH I-131 BDP3

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  • 1 August 1986
    • journal article
    • research article
    • Vol. 27  (8) , 1255-1261
Abstract
The kinetics, dosimetry, and response of iodine-131 .alpha.-amino-(4-hydroxybenzylidene)-diphosphonate ([131I]BDP3) treatment were investigated with patients with had pain symptoms from bone metastases of various primary carcinoma. The blood clearance of [131I] BDP3 was rapid. More than 90% disappeared from the blood pool at 2 hr after injection. The excretion of the activity occurred solely through the kidneys and mean total-body retention at 48 hr was 48.6%. The urinary activity showed a metabolite which must be formed by an in vivo cleavage reaction of a phosphorus-carbon bond. The uptake of in vivo cleaved [131I] iodide in the unblocked thyroid was .apprx. 0.5%. The effective half-life of [131I]BDP3 in metastatic bone (median 182 hr; range 177-205 hr) proved to be longer than in unaffected areas (145 hr; 140-165 hr). Palliative therapies were performed with 18 patients. They received doses ranging between 6 and 48 mCi [131I]BDP3. The response was 44% complete pain relief, 6% substantial pain relief, 22% minimal improvement, and 28% no change. The duration of response ranged between 1 and 8 wk.