[Long-term efficacy of hepatitis B vaccine in newborn and revaccination study].

  • 1 April 1994
    • journal article
    • clinical trial
    • Vol. 15  (2) , 76-9
Abstract
Two-hundred and sixty-nine newborns were followed up for 4 and 5 years after completion of vaccination (10 micrograms x 3). The anti-HBs positive rates remained 82.54% and 72.03%, respectively. The low-level titer (> or = 10-99 mIU/ml) made up 44.61%, and the medium-level titer (> or = 100-99mIU/ml) 32.34%. The highest titer was 857 mIU/ml. A 10 micrograms dose of hepatitis B vaccine was given to these children. The anti-HBs level went up greatly in the first month after revaccination, but started to drop in the third month, decreased rapidly in the sixth month, and in the twelveth month the level trended to restore the level before revaccination. This paper indicated that the home-made hepatitis B vaccine was effective. Revaccination was not necessary within 5-7 years after initial vaccination. Revaccination to children whose anti-HBs level was < 10mIU/ml was beneficial but the anti-HBs persistence was short.

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