Different Responses of Two Mouse Strains to 650 Rads and Protection by Surgical Stress
- 1 April 1975
- journal article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 148 (4) , 1095-1100
- https://doi.org/10.3181/00379727-148-38695
Abstract
Radiation survival of C57B1/6J mice after 650 rads improved from 1.7% to 66% when mice were stressed surgically one week before irradiation. Surgical stress one or three weeks before irradiation increased endogenous CFUs and decreased exogenous CFUs in C57B1/6J and DBA/1J mice. Survival may be related to the proportion of stem cells in different phases of the cell cycle, which was abnormal in C57B1/6J mice and compensated for by a greater number of nucleated cells per femur.Keywords
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