Asymmetric Synthesis of Both Enantiomers of α-Trifluoromethyl Substituted Homoallylamine
- 20 November 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2002 (17) , 2585-2588
- https://doi.org/10.1055/s-2002-35631
Abstract
An efficient asymmetric synthesis of both enantiomers of α-trifluoromethylated homoallylamine via nucleophilic allylation of trifluoroacetaldehyde SAMP- or RAMP-hydrazone, followed by benzoylation and SmI2-promoted nitrogen-nitrogen single bond cleavage is described.Keywords
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