Assessment of a DJ-1 ( PARK7 ) polymorphism in Finnish PD
- 14 October 2003
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 61 (7) , 1000-1002
- https://doi.org/10.1212/01.wnl.0000083992.28066.7e
Abstract
Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson’s disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.Keywords
This publication has 8 references indexed in Scilit:
- Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutationAnnals of Neurology, 2003
- Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset ParkinsonismScience, 2003
- Functional association of the parkin gene promoter with idiopathic Parkinson's diseaseHuman Molecular Genetics, 2002
- Genetics of parkinsonismMovement Disorders, 2002
- Familial Aggregation of Parkinson DiseaseArchives of Neurology, 2002
- alpha-synuclein gene haplotypes are associated with Parkinson's diseaseHuman Molecular Genetics, 2001
- Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoterGene, 2001
- Familial Aggregation of Parkinson's Disease in IcelandNew England Journal of Medicine, 2000