Metabolism bySchistosoma mansoniof a new schistosomicide: 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acid

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Abstract
SUMMARY: In order to investigate the mode of action of a new class of schistosomicides, theN-alkylaminoalkanethiosulphuric acids, the ‘outer35S] 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acid was synthesized. Labelling studies of adultSchistosoma mansoniwere performed in infected mice and inin vitroincubations. After a single oral dose of the drug to infected mice, 5 metabolites were detected by thin-layer chromatography in organic extracts of male and female adult schistosomes.In vitrostudies showed that the same compounds were present in organic extracts obtained from adult male and female worms. One of these metabolites was identified by mass spectroscopy as being the dimeric disulphide derivative of the parent labelled thiosulphuric acid.

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