Synthesis and .beta.-adrenergic blocking activity of new aliphatic oxime ethers
- 1 June 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (6) , 620-624
- https://doi.org/10.1021/jm00180a007
Abstract
New .beta.-adrenergic blocking agents, most of which do not contain an aromatic nucleus, were synthesized. They were derived from alkylamino-aliphatic oxime ethers or alkylamino-aliphatic ethers. Most active among these are O-[3-(tert-butylamino)-2-hydroxypropyl]acetoxime (8; trachea pA2 [effective concentration of agonist to antagonist] = 7.65) and 1-isobutoxy-3-(tert-butylamino)-2-propanol (15; trachea pA2 = 7.49), both of which displayed bronchoselectivity (.beta.2/.beta.1 ratio .apprx. 15) in guinea pigs. The role and importance of the aromatic nucleus in this class of compounds are discussed.This publication has 0 references indexed in Scilit: