“Sebaceous Glands” and “Hyperplasia” Tests as Screening Methods for Tobacco Tar Carcinogenesis

Publisher Website
Google Scholar
Abstract
There was close correlation between the activity in short-term tests of four cigarette smoke condensates applied to mouse skin and their carcinogenicity, or perhaps cocarcinogenicity. Cigarettes were made either from ribs (R = the midribs and the main veins of the tobacco leaves) or from parenchyma (P = portion of tobacco leaves free of midribs and veins). By adding a humectant (H) to two lots of cigarettes, we obtained four kinds: HR, R, HP, and P, with respectively increasing activity in the sebaceous-gland and hyperplasia tests. In long-term tests, we found the same progression of activity. These results indicate that short-term tests may be used for screening in tobacco-tar carcinogenicity research and also confirm again the correlation between short-term activity and carcinogenicity.

This publication has 0 references indexed in Scilit: