The response of the rat tail to hyperthermia

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Abstract
When the cartilage of the tail of a baby rat is exposed to temperatures between 41.degree. and 46.degree. C either necrosis or a small degree of stunting in growth may occur. Isoeffect curves relating time and temperature for both these endpoints for normal and clamped tissue were parallel, a doubling of heating time or an increase in temperature of 1.degree. C having the same effect in all cases. Clamping sensitizes the tails by a factor of about 3 in heating time, equivalent to a temperature difference of 1.5.degree. C. Arrhenius plots show an inactivation energy of 140 kcal/mol. This is similar to that found by other workers using different end-points and supports the suggestion that protein denaturation is a critical target for direct heat damage.

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