RELATIONSHIP BETWEEN DIURNAL VARIATIONS IN URINARY VOLUME AND THE EXCRETION OF ANTIDIURETIC SUBSTANCE*
- 1 January 1956
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 16 (1) , 28-34
- https://doi.org/10.1210/jcem-16-1-28
Abstract
Urines of 9 normal subjects, 6 patients with cardiac failure, and 5 patients with hepatic cirrhosis and ascites were assayed for antidiuretic substances (ADS) by a modification of the extraction method of Noble et al. and the bioassay technique of Burn. Contrary to results of previously published studies, the normal subjects were found to excrete as much or more ADS as patients with cardiac and hepatic disease. It is possible that the modified recovery method retained ADS which is ordinarily lost in dialysis. Comparison of urines obtained during periods of diuresis (morning collections in normal subjects; night collections in patients) with urines obtained during periods of antidiuresis revealed that in 15 paired specimens the greatest recovery of ADS coincided with the larger urinary volume, and in 6 the greatest recovery of ADS coincided with the smaller urinary volume. These observations fail to support the concept that ADS is the factor which regulates the diurnal rhythm of urinary flow.Keywords
This publication has 1 reference indexed in Scilit:
- THE RELATION BETWEEN CLINICAL EDEMA AND THE EXCRETION OF AN ANTIDIURETIC SUBSTANCE IN THE URINEAnnals of Internal Medicine, 1940