Deletion mapping of polymorphic loci by apparent parental exclusion
- 1 January 1983
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 14 (1) , 43-48
- https://doi.org/10.1002/ajmg.1320140108
Abstract
Deletion of a chromosome region containing a polymorphic marker may result in apparent parental exclusion at that locus. We present a general method for calculating the probability that deletion at a specific locus would have such an effect. For many autosomal loci this probability is substantial, justifying attempts at deletion mapping in most cases. This method may be especially valuable in assigning DNA restriction fragment polymorphisms to chromosome regions.Keywords
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