Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts
- 31 August 2005
- journal article
- research article
- Published by Springer Nature in European Journal of Nutrition
- Vol. 45 (3) , 144-151
- https://doi.org/10.1007/s00394-005-0574-7
Abstract
Polyunsaturated fatty acids (PUFAs) modulate immune responses particularly by affecting T cell function and are applied clinically as adjuvant immunosuppressants in the treatment of various inflammatory diseases. However, the molecular mechanisms of PUFA–induced immunosuppressive effects are not yet elucidated. Membrane lipid rafts are functional plasma membrane microdomains characterized by a unique lipid environment. Since lipid interactions are crucial for the formation of lipid rafts, the immunomodulatory effects of PUFAs may be due to changes of fatty acid composition in lipid rafts.Keywords
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