McCune-Albright Syndrome With Endocrinological Investigations

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Abstract
The uncommon clinical syndrome of sexual precocity, polyostotic fibrous dysplasia, and cutaneous pigmentation was first described by Mc-Cune1 and Albright et al.2 The sexual precocity has been ascribed to premature activation of the normal mechanisms initiating puberty,3 although ovulation in the chronologically prepubertal female subject with McCune-Albright's syndrome has never been demonstrated. Spermatogenesis before the normal age of puberty has been reported in a single case.4 We report a further case of McCune-Albright's syndrome in which the excretion of urinary estriol was unusually high as were serum growth hormone levels following insulin induced hypoglycemia. The excretion of urinary luteinizing hormone by a radioimmunoassay method5 was also measured. Report of a Case First Admission.—The patient, a 9-year-old girl, was first admitted to hospital aged 3 months because of vomiting and vaginal bleeding. At laparotomy, an infarcted right ovary, thought to be secondary to torsion of

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