Induction of diabetes by cumulative environmental insults from viruses and chemicals
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5789) , 383-385
- https://doi.org/10.1038/288383a0
Abstract
When strains of mice normally resistant to encephalomyocarditis virus (EMC)-induced diabetes were first treated with sub-diabetogenic doses of streptozotocin, then infected with EMC, diabetes developed. When mice were infected with coxsackieviruses B3 and B5, which ordinarily produce little if any, .beta.-cell damage, diabetes developed if the mice were first treated with sub-diabetogenic doses of streptozotocin. Diabetes may result from cumulative .beta.-cell damage induced by sequential environmental insults.Keywords
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