The inhibition of 3α-hydroxy steroid-activated nicotinamide-adenine dinucleotide (phosphate) transhydrogenase by some antimetabolic compounds

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Abstract
This work establishes the inhibition in vitro of the 3a-hydroxy steroid-activated NAD(P)-transhydrogenating enzyme system from rat liver by certain derivatives of purines and pyrimidines. Of the compounds tested the most active purine and pyrimidine analogues appear to be those having a high therapeutic index against experimental cancer. The inhibition produced is additive as between purines and pyrimidines and also between inhibitory steroid hormones and the antimetabolites.