Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
- 1 November 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5940) , 239-242
- https://doi.org/10.1038/306239a0
Abstract
The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph'') chromosome, in chronic myelocytic leukemia (CML). The position of the Ph'' chromosomal break point is variable and, in 1 CML patient, was localized immediately 5'' of, or within, the c-abl oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.This publication has 31 references indexed in Scilit:
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