Circadian Rhythms in Human Heart Homograft
- 14 August 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3946) , 694-696
- https://doi.org/10.1126/science.169.3946.694
Abstract
The electrocardiogram and cardiotachogram of a patient with a human heart transplant has been recorded for 72 hours. Within the donor P-QRS-T complex, one can identify the P waves emanating from residual sinoatrial heart tissue of the recipient. The recipient P waves are independent of the donor complexes. A clear circadian rhythm (23.4 hours) in heart rate is maintained for both donor and recipient tissue, the donor complexes preceding by a phase shift of 135 minutes the complexes of the recipient heart tissue. Both tissues display clear morning and evening minimum and maximum rates paralleling activity and lighting cycles.Keywords
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