Clinical Results of Treatment of Diabetes Insipidus with Drugs of the Chlorothiazide Series

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Abstract
DIABETES insipidus ordinarily is due to lack of the neurohypophyseal hormone, vasopressin, which enables the kidneys to form concentrated urine. Treatment consists of administering material obtained from animal sources intranasally, sublingually or intramuscularly. To control polyuria adequately with the first two routes, treatment must be repeated on the average four times daily whereas the preparation for intramuscular use, in which the hormone is tannated and suspended in oil, provides relief for approximately forty-eight hours. Less commonly, a nephrogenic type of the disease is encountered. Here, endogenous hormone is formed in abundance, but the kidney fails to respond to it. Moreover, . . .