Multiple-dose ciprofloxacin kinetics in normal subjects

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Abstract
To determine multiple-dose kinetics of the quinoline carboxylic acid derivative ciprofloxacin, 12 normal subjects were given ciprofloxacin, 250 mg by mouth every 12 h for 13 doses. Plasma concentrations were measured by high-pressure liquid chromatography after the 1st, 7th, and 13th doses. Peak and trough plasma concentrations were measured daily. Ciprofloxacin was rapidly absorbed from the gastrointestinal tract and reached maximum serum concentrations .apprx. 1 h after dosing. Ciprofloxacin elimination t1/2 increased from 3.71 h after the 1st dose to 6.51 h after the 13th dose (P < 0.05). Apparent plasma clearance decreased from 0.823 to 0.629 l/kg/h because of decreased nonrenal clearance. Drug cumulation did not occur throughout the experiment. Evidently, concentrations of ciprofloxacin in excess of the minimum inhibitory concentrations for many important pathogens can be achieved in plasma, and controlled clinical trials of ciprofloxacin efficacy in selected systemic infections are warranted.

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