Genetic Effects of Combined Chemical-X-ray Treatments in Male Mouse Germ Cells

1 January 1987

journal article
research article
Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

Vol. 51 (6) , 985-996
https://doi.org/10.1080/09553008714551281

Abstract

Several studies have shown that the yield of genetic damage induced by radiation in male mouse germ cells can be modified by chemical treatments. Pre-treatments with radio-protecting agents have given contradictory results but this appears to be largely attributable to the different germ cell stages tested and dependent upon the level of radiation damage induced. Pre-treatments which enhance the yield of genetic damage have been reported although, as yet, no tests have been conducted with radio-sensitizers. Another form of interaction between chemicals and radiation is specifically found with spermatogonial stem cells. Chemicals that kill cells can, by population depletion, substantially and predictably modify the genetic response to subsequent radiation exposure over a period of several days, or even weeks. Enhancement and reduction in the genetic yield can be attained, dependent upon the interval between treatments, with the modification also varying with the type of genetic damage scored. Post-treatment with one chemical has been shown to reduce the genetic response to radiation exposure.

Keywords

This publication has 34 references indexed in Scilit:

Antimutagenic properties of selected radioprotective drug mixtures with regard to X-ray-induced reciprocal translocations in mouse spermatogonia
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1986
Enhanced radiosensitivity for the induction of translocations in mouse stem cell spermatogonia following treatment with cyclophosphamide or adriamycin
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1984
Evidence for the re-establishment of a heterogeneity in radiosensitivity among spermatogonial stem cells repopulating the mouse testis following depletion by X-rays
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1984
Modified genetic response to X-irradiation of mouse spermatogonial stem cells surviving treatment with TEM
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
Evidence of a threshold x-ray dose for sensitizing stem-cell spermatogonia of the mouse to the induction of chromosomal translocations by a second larger one
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
Translocation yield from mouse spermatogonial stem cells following unequal-sized X-ray fractionations: Evidence of radiation-induced loss of heterogeneity
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
Protection of the mouse from genetic radiation damage by an optimal-dose-ratio combination of ATP, AET, and serotonin
Cellular and Molecular Life Sciences, 1978
Translocation yield from the mouse spermatogonial stem cell following fractionated X-ray treatments: Influence of unequal fraction size and of increasing fractionation interval
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
Protection of mouse spermatogonia against X-ray induced translocations
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Spermatogonial stem cell killing in the mouse following single and fractionated X-ray doses, as assessed by length of sterile period
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974