A70104 and food intake in pigs
- 1 May 1993
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 4 (5) , 495-498
- https://doi.org/10.1097/00001756-199305000-00008
Abstract
The aim of the present study was to determine whether CCK released from the small intestine during a meal acts as a satiety factor. The effects of the novel CCKA antagonist A70104 (50–200 μg kg−1, i.v.) were investigated on operant food intake in 4 h food-deprived pigs. None of the doses used had any significant effects on the amount of food consumed by the animals over the 2 h measurement period. However, pretreatment of the pigs with A70104 (100 μg kg−1) did block the inhibitory effect of exogenous CCK (1 μg kg−1, i.v.) on operant feeding. These results thus question the validity of the hypothesis that endogenous peripheral CCK acts as a satiety factor.Keywords
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