EFFECT OF ACUTE-PANCREATITIS ON PULMONARY TRANS-VASCULAR FLUID AND PROTEIN EXCHANGE

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Abstract
Anesthetized sheep lung lymph preparation was used to examine the effects of acute hemorrhage pancreatitis on pulmonary transvascular fluid and protein exchange. Induction of acute pancreatitis by injection of trypsin and sodium taurocholate into the pancreatic duct caused significant increases (P < 0.05) in lung lymph flow, ratio of lymph to plasma protein concentration (L/P ratio) and transvascular protein clearance. Pulmonary arterial and pulmonary arterial wedge pressures did not change significantly, but pulmonary blood flow decreased (P < 0.05) and pulmonary vascular resistance increased (P < 0.05). In contrast to the effects of acute pancreatitis, left atrial hypertension caused increases in lung lymph flow that were associated with decreases in the L/P ratio. Extravascular lung water content was increased after acute pancreatitis by 25% from the value obtained in sham-operated animals in which saline was injected into the pancreatic duct. Apparently, acute hemorrhagic pancreatitis causes an increase in pulmonary vascular permeability to proteins. Because pulmonary vascular pressures did not change, the increased permeability may be due to cellular and humoral factors rather than hemodynamic mechanisms.

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