RED-CELL 2,3-DIPHOSPHOGLYCERATE AND OXYGEN-AFFINITY OF HEMOGLOBIN IN PATIENTS WITH THYROID DISORDERS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (1) , 181-185
Abstract
Red blood cell 2,3-diphosphoglycerate (2,3-DPG), ATP and the P50 value in vitro of the HbO2 dissociation curve (which is the oxygen tension at half saturation of Hb) were measured to quantitate red blood cell oxygen transport function in individuals who were diagnosed as hypothyroid, euthyroid or hyperthyroid. Diagnosis was based on measurements of thyroxine (T4), triiodothyronine (T3), thyrotropin (TSH) and clinical status. Hypothyroid (mean T4 2.8 .mu.g/dl, T3 49 ng/dl, TSH 37 .mu.U[units]/ml) and hyperthyroid (mean T4 14 .mu.g/dl, T3 271 ng/dl, TSH < 0.7 .mu.U/ml) patients had normal red cell 2,3-DPG and ATP levels and normal P50 values in vitro. The known changes in oxygen consumption produced by alterations in thyroid hormone levels in patients with hypothyroidism or hyperthyroidism did not affect red blood cell oxygen transport function.

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