Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia
- 1 July 2001
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 114 (1) , 70-77
- https://doi.org/10.1046/j.1365-2141.2001.02895.x
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemiaBlood, 2000
- Flavopiridol Induces Apoptosis in Chronic Lymphocytic Leukemia Cells Via Activation of Caspase-3 Without Evidence of bcl-2 Modulation or Dependence on Functional p53Blood, 1998
- Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo ChemoresponsesBlood, 1998
- Regulation of p53 stability by Mdm2Nature, 1997
- Flow cytometric analysis of the early phases of apoptosis by cellular and nuclear techniquesCytometry, 1996
- Bcl‐2, Bax and p53 expression in B‐CLL in relation to in vitro survival and clinical progressionInternational Journal of Cancer, 1996
- Tumor suppressor p53 is a direct transcriptional activator of the human bax geneCell, 1995
- p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expressionBlood, 1993
- bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemiaBlood, 1993
- A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysisCancer, 1981