Enantioselective reformatsky reaction of methyl bromodifluoroacetate
- 1 August 1995
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1995 (8) , 1447-1450
- https://doi.org/10.1002/jlac.1995199508196
Abstract
The Reformatsky reagent 2 generated from methyl bromodifluoroacetate is added to benzaldehyde in the presence of carbinols 3a, b, amino alcohols 3c‐g, or amino alkoxide 3h. N‐Methylephedrine 3c provides the highest enantioselectivity in the formation of the adduct S‐4a (84% ee; >96% after recrystallization) whose absolute configuration is determined by an X‐ray structural analysis of the amide 6.Keywords
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