Synthese von Cystinpeptiden mit Sequenzen aus dem C‐terminalen Bereich der Humaninsulin‐A‐Kette
- 22 October 1968
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 716 (1) , 164-174
- https://doi.org/10.1002/jlac.19687160124
Abstract
Die teilweise geschützten Cysteinpeptide Z‐Glu(OBut)‐Asn‐Tyr‐Cys(Bzl)‐Asn, Z‐Leu‐Tyr‐Gln‐Leu‐Glu‐Asn‐Tyr‐Cys(Bzl)‐Asn (3) und Z‐Ile‐Cys(Bzl)‐Ser‐Leu‐Tyr‐Gln‐Leu‐Glu‐Asn‐Tyr‐Cys(Bzl)‐Asn (13), die den Sequenzen 17‐21, 13‐21 und 10‐21 in der A‐Kette des Humaninsulins entsprechen, wurden durch Fragmentkondensation aufgebaut (vgl. Schema S. 166), durch Behandeln mit Natrium in flüssigem Ammoniak deblockiert und anschließend durch Luftoxydation in die Cystinpeptide 14‐16 übergeführt.Keywords
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