Exercise Fitness, Cardiac Work and Blood Viscosity Factors in Patients and Normals

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Abstract
A study of 41 cardiovascular patients and normals showed significant correlations between physical fitness (as expressed by a fitness index based on work output) and high shear rate blood viscosity (p < 0.01); between the cardiac work expressed as double product (= myocardial oxygen demand) and aggregation of red cells (p < 0.05); between the triple term of cardiac work (fitness index divided by double product) and high shear rate blood viscosity (p < 0.005) or aggregation of red cells (p < 0.05), in all cases correlations being negative, i.e., higher cardiac work or higher fitness being related to low blood viscosity or lower aggregation of red cells. Significant differences were found between high-fitness and low-fitness groups, the high-fitness group showing lower plasma viscosity (p < 0.005), lower blood viscosity (p < 0.0025), lower aggregation of red cells (p < 0.05), lower fibrinogen level (p < 0.05), and higher albumin/fibrinogen ratio (p < 0.01).

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