Metabolism and Urinary Excretion of Chlormethiazole in Humans
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (11) , 687-696
- https://doi.org/10.3109/00498257509056138
Abstract
1. Chlormethiazole and five of its metabolites excreted in urine in man have been investigated by g.l.c.-mass spectrometry. 2. Four metabolites have been identified by comparison with authentic compounds as 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyl)-4-methylthiazole, 5-(2-hydroxyethyl)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid; 4-methyl-5-thiazoleacetaldehyde is proposed for the other metabolite. 3. The amounts of chlormethiazole and its identified metabolites excreted in urine have been quantitatively determined after a single oral dose in three healthy adults. Approximately 16% of the dose was excreted as chlormethiazole, 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyx)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid.Keywords
This publication has 8 references indexed in Scilit:
- Pharmacokinetics of chlormethiazole in humansEuropean Journal of Clinical Pharmacology, 1975
- Metabolism studies of chlormethiazole by gas chromatography-mass spectrometryInternational journal of legal medicine, 1973
- Stoffwechsel von chlormethiazol in der zyklisch perfundierten leber der ratteBiochemical Pharmacology, 1973
- Stoffwechsel von Chlormethiazol in der RatteNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1971
- Vävnadsdistribution, utsöndring och metabolism för Heminevrin (4-metyl-5- β -kloretyltiazol-etandisulfonat)Nordisk Psykiatrisk Tidsskrift, 1963
- Thiamin Analogs. II. 4-Methylthiazole Analogs1,2Journal of the American Chemical Society, 1945
- Studies on Thiazoles. I. 4-Methylthiazole-5-acetic Acid and Some of its DerivativesJournal of the American Chemical Society, 1937
- Studies of Crystalline Vitamin B1. III. Cleavage of Vitamin with SulfiteJournal of the American Chemical Society, 1935