A COMPARISON OF TINE AND MONO-VACC TESTS WITH INTRADERMAL TUBERCULIN TEST

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Abstract
Tuberculin skin tests by 3 methods were performed on 670 persons. Duplicate tests by each method were performed on a randomly selected 1/3 of the population. All readings were performed in duplicate by 2 readers. Duplicate tests given by the Mantoux method agreed in 75 to 78% of the readings at 48 hr. Between 1 and 2% of the readings varied by 10 mm. or more. Specificity (false-positive) and sensitivity (false-negative) reactions varied about 2% when compared with the 1st Mantoux as the standard. Duplicate tine tests agreed in 76 to 79%, and only 0.4 to 0.8% differed by 10 mm. or more. Specificity and sensitivity show double the error of the Mantoux test (about 4%). Duplicate Mono-Vacc tests agreed in 68 to 72% of the cases. Only 0.4 to 2.2%: of the reactions differed by 10 mm. or more. Specificity showed 4 to 9% false-positive reactions and 3 to 5% false-negative reactions. The amount of disagreement between 2 readers reading the same test was 1.2% with the Mantoux, 3.3% with the tine, and 5.1% with the Mono-Vacc test. False-positive reactions were observed in about 6% of persons tested by the tine method and 11 to 14% tested by the Mono-Vacc method.

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