Transfer of Antibiotic Resistance in Mixed Cultures of Neisseria gonorrhoeae

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Abstract
Resistance to spectinomycin, streptomycin, rifampin, and erythromycin was transferable during mixed-broth cultivation of sensitive and resistant strains of Neisseria gonorrhoeae. Resistance to each drug was ordinarily transferred independently of resistance to the others. Resistance was not transferred in the presence of DNase, and transfer was most probably due to transformation of competent clonal type 1 or 2 recipients by DNA liberated from the donor strain into the culture broth. The results are of potential relevance to clinical problems of development and spread of antibiotic-resistant gonococci.

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