Emetic and Hyperthermic Effects of Centrally Injected Methionine-Enkephalin in Cats
- 1 April 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 154 (4) , 540-542
- https://doi.org/10.3181/00379727-154-39713
Abstract
Summary Third cerebral ventricular administration of 1-2 mg of methionine-en-kephalin caused both emesis and hyperther-mia in cats. The emetic response was prevented, and the hyperthermic response was reduced by 100-250 μg of naloxone given intraventricularly 30 min before enkepha-lin. These results provide further evidence that enkephalins can act on opiate receptors in the brain. This investigation was supported by USPHS Research Grant NS 08618.1 would like to thank Ms. Jean Ann Robins for her technical assistance.This publication has 4 references indexed in Scilit:
- Physical Dependence of Opiate-Like PeptidesScience, 1976
- Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analoguesLife Sciences, 1976
- Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brainLife Sciences, 1976
- Volumetric compartmentalization of the cranial cerebrospinal fluid system determined radiographically in the catThe Anatomical Record, 1966