Experiments on infarct genesis caused by blockage of carbohydrate metabolism in guinea pig placentae

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Abstract
Summary The poisoning of pregnant guinea pigs with monoiodineacetate, an inhibitor of carbohydrate metabolism in the glyceraldehyde-3-phosphate dehydrogenase phase, leads within a few minutes to the formation of syncytial plasma protrusions in the maternal blood lacunae of the placenta. These protrusions cause a primary white infarct where the degenerative process takes place—in the interlobium. An accumulation of erythrocytes originates in its arterial inflow area owing to the obstruction of the blood flow. Both primary infarct and accumulation of erythrocytes alter to form a single homogenous white infarct within a few days, together with the degenerative products of all cellular and syncytial elements. Timely substitution of glycolysis for pyruvate, i.e. within 20 min, during continued blockage of the glyceraldehyde-3-phosphate dehydrogenase, prevents the formation of an infarct.