Enhanced Hepatic Microsomal Activity by Pretreatment of Rats with Acetone or Isopropanol
- 1 January 1973
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 142 (1) , 237-240
- https://doi.org/10.3181/00379727-142-36996
Abstract
Summary Rat liver microsomes isolated from rats pretreated orally with acetone or isopropanol possessed an enhanced capacity to bind 14CCl4 and 14CHCl3 covalently and to demethylate DMN. The N-demethylation of ethylmorphine was unchanged by this pretreatment. Since there was no increase in the level of microsomal protein, and microsomal cytochrome P-450 or the activity of NADPH-cytochrome c reductase, the mechanism of this enhanced metabolism remains unclear. The authors acknowledge the excellent technical assistance of E. M. Boykins, M. A. Williams and W. Saul.This publication has 0 references indexed in Scilit: