Primaquine analogs: derivatives of 4-amino-2-methoxyacridine
- 1 October 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (10) , 1164-1167
- https://doi.org/10.1021/jm00196a003
Abstract
Based on the antimalarial activity of primaquine and its 4-methyl analog, 4-aminoacridinyl analogs, 4-[(4-amino-1-methylbutyl)amino]-2-methoxyacridine and 4-[(4-amino-1-methylbutyl)amino]-2-methoxy-9-methylacridine, were prepared and evaluated as potential tissue schizonticidal agents. These compounds were substantially less active than primaquine against Plasmodium cynomolgi in the rhesus monkey. The antileishmanial activity in hamsters of 4-[[6-(diethylamino)hexyl]amino]-2-methoxy-9-methylacridine was considerably less than that of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline.This publication has 0 references indexed in Scilit: