Renin Secretion after Papaverine and Furosemide in Conscious Sheep

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Abstract
Conscious sheep with chronically implanted vascular catheters and a renal artery flow probe were used to study the effects of papaverine alone or papaverine plus furosemide on renin secretion. Papaverine infused into the renal artery at 7 mg/min produced a significant renal vasodilation which was not further enhanced by increasing the papaverine infusion to 10 mg/min. GFR [glomerular filtration rate] decreased significantly as did the filtered load of Na. The increased Na excretion reported in anesthetized dogs was not observed in conscious sheep. Renin secretion was not altered despite these changes in renal function. When 35 mg of furosemide was administered i.v. in addition to the renal artery papaverine infusion, no further change in RPF [renal plasma flow] or GFR was observed. Na excretion was significantly elevated at each clearance period after furosemide administration and these increases were closely paralleled in time by large increases in renin secretion. The increased renin secretion observed from the papaverine blocked kidney after furosemide administration appeared to be mediated by changes in ion transport by the renal tubules and not by activation of the intrarenal baroreceptor.

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