Strontium85 Metabolism in Man and Effect of Calcium on Strontium Excretion.

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Abstract
Metabolism of radiostrontium was studied in man using carrier-free Sr85, a pure [gamma]-emitter with a 65-day half-life. 0.1-0.4 [mu]c Sr85/kg body weight were injected intravenously and the plasma levels, urinary and fecal excretions of Sr85 were followed up to 24 days. Studies indicate that Sr85 metabolism reflects well the Ca metabolism and state of the skeleton. Significant differences of the plasma levels and major differences of urinary Sr85 excretion were noted in patients with Paget''s disease and senile osteoporosis, as compared to normals. Marked enhancement of urinary radio-strontium excretion was noted when intravenous Ca in the form of calcium gluconate was injected together with Sr85.

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