Yttrium-90 (90Y) Ibritumomab Tiuxetan (Zevalin®) Induces Long-Term Durable Responses in Patients with Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma

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Abstract
Aim: Yttrium-90 (90Y) ibritumomab tiuxetan (Zevalin®) radioimmunotherapy is an effective treatment for relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL), with overall response rates ranging from 74% to 82%. This retrospective analysis was conducted to determine the number of patients achieving long-term durable responses with 90Y ibritumomab tiuxetan treatment. Materials and Methods: The medical records of patients (n = 211) with relapsed, refractory, or transformed indolent CD20+ B-cell NHL who were treated with 90Y ibritumomab tiuxetan were reviewed. Time to progression (TTP) of ≥12 months was noted in 78 patients (37%), who were identified as long-term responders and were further characterized. Results: Median age of the long-term responders was 58 years (range, 24–80 years) with 44% over 60 years, and 55% were male. Notably, 59% of patients had received ≥2 prior regimens, 33% had received ≥3 prior regimens, and 37% had failed to respond to immediate prior therapy. Median response duration was 28.1 months (range, 10.5–80.3+ months). Median TTP was 29.3 months (range, 12.1–81.5+ months). In patients with ongoing response, median TTP was 53.9 months (range, 49–82+ months). Conclusions:90Y ibritumomab tiuxetan produces durable long-term responses in patients with relapsed/refractory B-cell NHL. Failure to respond to prior therapy does not preclude achieving a long-term response with 90Y ibritumomab tiuxetan.