The Production of a State of Active Immunity to Isologous and Autologous Serum Proteins

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Abstract
Acute hypogammaglobulinemla and hypoalbuminemia of varying duration and severity were produced in dogs by inducing an active state of immunity against isologous [gamma]-globulin or autologous albumin. This was accomplished by coupling isologous dog [gamma]-globulin or autologous dog albumin to a highly antigenic protein (human [gamma]-globulin) by means of a bisdlazobenzidine linkage, and reintroducing these complexes into dogs. The presence of specific antibody to dog [gamma]-globulin and albumin was demonstrated in a number of the hypogammaglobu-linemic and hypoalbuminemic animals, thereby indicating that these experimental results had an immunologic basis.

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