Failure to Validate Association between 12p13 Variants and Ischemic Stroke
- 22 April 2010
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 362 (16) , 1547-1550
- https://doi.org/10.1056/nejmc0910050
Abstract
Recently published data from a meta-analysis of genomewide association studies showed that two common single-nucleotide polymorphisms (SNPs) near the NINJ2 and WNK1 genes on chromosome 12p13 were associated with ischemic and, in particular, atherothrombotic strokes.1 To validate these results, we conducted a meta-analysis in a combined sample of 8637 cases and 8733 controls of European ancestry, as well as one population-based genomewide cohort study of 278 ischemic strokes among 22,054 participants.Keywords
This publication has 3 references indexed in Scilit:
- Genomewide Association Studies of StrokeNew England Journal of Medicine, 2009
- Meta-analysis in genome-wide association studiesPharmacogenomics, 2009
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke, 1993