Genetic Susceptibility to AIDS: Absence of an Association with Group-Specific Component (Gc)

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Abstract
To the Editor: Differences in human susceptibility to the acquired immunodeficiency syndrome (AIDS) are suggested by the observation that only a fraction of persons exposed to the human immunodeficiency virus (HIV) become infected1 and by the considerable variation in the pace of disease progression among infected persons.2 , 3 These differences may be due in part to natural genetic variation in DNA sequences influencing viral infectivity or immune response. In a recent article in the Lancet, Eales et al. reported that alleles at the group-specific component (Gc) locus were differentially associated with AIDS and other clinical manifestations of HIV infection in . . .