Varicella-zoster virus vaccine DNA differs from the parental virus DNA
- 1 October 1981
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 40 (1) , 314-318
- https://doi.org/10.1128/jvi.40.1.314-318.1981
Abstract
The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.This publication has 24 references indexed in Scilit:
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