Genetic linkage of hereditary motor and sensory neuropathy type I (Charcot‐Marie‐Tooth disease) to markers of chromosomes 1 and 17
- 1 September 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (9) , 1450
- https://doi.org/10.1212/wnl.40.9.1450
Abstract
Hereditary motor and sensory neuropathy type 1 (HMSN I) is an autosomal dominant disorder genetically localized on chromosome 1 in a few families and on chromosome 17 in other families. We analyzed linkage between 6 markers of chromosome 1, 2 markers of chromosome 17, and the HMSN I locus using restriction fragment length polymorphisms and serotyping for the Duffy blood group in 5 families with HMSN I. Only in 1 of these families is linkage present between the disease locus and the loci for Duffy blood group and glucocerebrosidase (chromosome 1 markers). In the 4 other families the HMSN I locus is linked to the chromosome 17 markers pEW301 and pA10–41.This publication has 5 references indexed in Scilit:
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