Polystyrene tube immunoradiometric assay for human alpha1-fetoprotein, and its use for mass screening.
Open Access
- 1 December 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 24 (12) , 2158-2160
- https://doi.org/10.1093/clinchem/24.12.2158
Abstract
We describe a two-site immunoradiometric assay for human alpha1-fetoprotein, with use of antibody-coated polystyrene tubes as solid phase. The sensitivity, precision, and simplicity of this system make it eminently suitable for mass-screening purposes. We currently use it for neonatal detection of hereditary tyrosinemia in the Province of Quebec; measurements are made on blood spotted and dried on paper. This system could be well suited for other mass surveys, such as prenatal screenings for fetal abnormalities.This publication has 4 references indexed in Scilit:
- Radioimmunoassay of alpha-fetoprotein, with special reference to iodination and purification techniques.Clinical Chemistry, 1978
- alpha1-Fetoprotein measurement in blood spotted on paper: discriminating test for hereditary tyrosinemia in neonatal mass screening.Clinical Chemistry, 1976
- Hematocrit values of capillary blood in the newborn infantThe Journal of Pediatrics, 1967
- THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYBiochemical Journal, 1963