LACK OF CORRELATION BETWEEN DELAYED-TYPE HYPERSENSITIVITY AND HOST-RESISTANCE TO PLASMODIUM-CHABAUDI INFECTION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 42  (3) , 421-427
Abstract
C57B1/6J mice immunized with P. chabaudi antigen plus saponin exhibited strong delayed-type hypersensitivity (DTH) reactions to footpad P. chabaudi injections. When immunized mice were challenged with P. chabaudi parasites. DTH was significantly depressed after 3 days of infection. This DTH depression coincided with a steep rise in the malarial antibody titer in these immunized challenged mice when compared to unchallenged immunized mice. Serum from mice recovering from P. chabaudi infection depressed DTH levels of immunized mice significantly, but spleen cells from convalescent mice only slightly reduced DTH levels. The role of cell-mediated immunity in malaria infections is discussed.