Studies of HIV-associated immune responses in lymphoid compartments
- 1 March 2006
- journal article
- review article
- Published by Springer Nature in Current HIV/AIDS Reports
- Vol. 3 (1) , 32-38
- https://doi.org/10.1007/s11904-006-0006-1
Abstract
Acute HIV-1 infection results in profound depletion of CD4+ memory T cells in lymphoid tissue (LT) and subsequent persistent replication in activated CD4+ T cells despite induction of an HIV-specific cell-mediated immune response. Interferon-α, proinflammatory cytokines, and β-chemokine production is present in LT. However, impaired expression of co-stimulatory molecules including CD80, CD86, and CD40L may contribute to low polyfunctional CD4+ T cell as well CD8+ T-cell activity. Accumulation of regulatory CD4+ T cells in LT may add to the lack of HIV-specific CD4+ T-cell proliferation and dysfunctional cytotoxic CD8+ T-cell response in LT.Keywords
This publication has 52 references indexed in Scilit:
- CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosisBlood, 2005
- Lymphoid Follicles Are Sites of Heightened Human Immunodeficiency Virus Type 1 (HIV-1) Replication and Reduced Antiretroviral Effector MechanismsAIDS Research and Human Retroviruses, 2005
- Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cellsNature, 2005
- HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cellsPLoS Biology, 2004
- Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaquesJournal of Medical Primatology, 2004
- HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative CapacityThe Journal of Experimental Medicine, 2003
- Levels of Interleukin?15 in Plasma May Predict a Favorable Outcome of Structured Treatment Interruption in Patients with Chronic Human Immunodeficiency Virus InfectionThe Journal of Infectious Diseases, 2003
- Trafficking of Human Immunodeficiency Virus Type 1-Specific CD8+T Cells to Gut-Associated Lymphoid Tissue during Chronic InfectionJournal of Virology, 2003
- T Cell Proliferation and Apoptosis in HIV-1-Infected Lymphoid Tissue: Impact of Highly Active Antiretroviral TherapyClinical Immunology, 2001
- Human Immunodeficiency Virus Type 1 Infection Is Associated with Significant Mucosal Inflammation Characterized by Increased Expression of CCR5, CXCR4, and β‐ChemokinesThe Journal of Infectious Diseases, 2000