Inclusion Complexes of Terfenadine-Cyclodextrins

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Abstract
Terfenadine, a poorly soluble, H1-antihistamine was solubilised using B-cyclodextrin and its derivatives. A molar ratio of 1:1 of the drug and cyclodextrin was prepared by the kneading method. The inclusion complex was characterised and evaluated by Differential Scanning Calorimetry & X-ray Diffractometry. In vitro dissolution profile of the inclusion complex was studied. Dissolution rates of the drug-cyclodextrin complexes were more as compared to the drug alone. An attempt was also made to prepare a palatable syrup of terfenadine-cyclodextrin complex. Various combination of co-solvents and additives were used to formulate a stable and an acceptable liquid oral.

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