Control of Noradrenaline Release from Hippocampal Synaptosomes

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Abstract
Potassium-evoked [3H]-noradrenaline (norepinephrine, NA) release from [rat] hippocampal synaptosomes was measured with a superfusion method. A single 2-min high-K+ pulse released 39% of the vesicular NA by a Ca2+-dependent mechanism; the Ca2+-independent release was negligible. After changing the vesicular NA store size by pretreating rats with either .alpha.-methyl-p-tyrosine, 500 mg/kg, or tranylcypromine, 10 mg/kg, a single K+ pulse released a constant percentage of the vesicular NA. With 2 K+ pulses there was a reduction in the percentage of vesicular NA released in response to the 2nd pulse.