Specific Immunologic Unresponsiveness to Synthetic Polypeptide Antigens
- 25 January 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 139 (3552) , 342-343
- https://doi.org/10.1126/science.139.3552.342
Abstract
The injection of two synthetic polypeptide antigens into adult rabbits treated with 6-mercaptopurine, or into newborn rabbits, resulted in immunological "unresponsiveness" to subsequent immunizations with these antigens. The "tolerant" animals were shown to be reactive toward the non-related antigen ovalbumin.Keywords
This publication has 7 references indexed in Scilit:
- Studies on the chemical basis of the antigenicity of proteins. 6. Antigenic specificity of some synthetic polypeptides containing tyrosineBiochemical Journal, 1963
- Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosineBiochemical Journal, 1962
- Antigenicity of Polypeptides (Poly-α-Amino Acids). IIThe Journal of Immunology, 1962
- Studies on Synthetic Polypeptide AntigensPublished by Elsevier ,1961
- Immunological Tolerance of Nonliving AntigensPublished by Elsevier ,1961
- A specific synthetic polypeptide antigenBiochimica et Biophysica Acta, 1960
- A strongly antigenic synthetic polypeptideJournal of Molecular Biology, 1960