Chromosome 17 Abnormalities and Inactivation of the P53 Gene in Chronic Myeloid Leukemia and Their Prognostic Significance

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Abstract
We have reviewed all the relevant studies on the loss of the short arm of chromosome 17 (17p) and inactivation of the p53 gene in chronic myelogenous leukemia (CML) in an attempt to clarify their roles in the progression of CML. Loss of a I7p (hemizygous I7p) and p53 inactivation emerged as the disease progressed and were closely associated with each other. About half of the cases with loss of a 17p, however, did not show pS3 inactivation. In these cases loss of a 17p preceded p53 inactivation, which suggested that either reduction of the p53 gene dosage or inactivation of another tumor-sup pressor gene on I7p might contribute to the diseasc progression. Both loss of a I7p and pS3 inactiation may serve as poor prognostic factors but the prognostic significance of the former only emerged when metaphase cells with loss of a 17p were dominant amongst the total cell population analyzed.